Literature base on the efficiency of nattokinase in dissolving fibrinogen and improving microcirculation

The following is the basis of the literature on the efficiency of nattokinase in dissolving fibrinogen and improving microcirculation:

1. Dissolved fibrinogen study:

Sumi, H., Hamada, H., Tsushima, H., Mihara, H., & Muraki, H. (1987). A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia, 43(10), 1110-1111.

Conclusion:This study found that nattokinase has potent fibrinolytic activity that directly dissolves fibrinogen and activates fibrinogen to promote fibrinolysis.

Research:Fujita, M., Nomura, K., Hong, K., Ito, Y., Asada, A., & Nishimuro, S. (1995). Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan. Biochemical and Biophysical Research Communications, 197(3), 1340-1347.

Conclusion:Studies have shown that nattokinase is effective in degrading fibrinogen and its activity is superior to that of fibrinolytic enzymes.

2. Improvement of microcirculation efficiency:

Hsia, C. H., Shen, M. C., Lin, J. S., Wen, Y. K., Hwang, K. L., Cham, T. M., & Yang, N. C. (2009). Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutrition Research, 29(3), 190-196.

Conclusion:Studies have shown that nattokinase reduces plasma fibrinogen levels and improves blood flow, thereby enhancing the efficiency of microcirculation.

Research:Pais, E., Alexy, T., Holsworth, R. E., & Meiselman, H. J. (2006). Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clinical Hemorheology and Microcirculation, 35(1-2), 139-142.

Conclusion:Nattokinase significantly improves microcirculation by lowering blood viscosity and reducing red blood cell aggregation.

Summary The above literature suggests that nattokinase is effective in improving the efficiency of microcirculation by dissolving fibrinogen and reducing blood viscosity. For further information, it is recommended to consult the relevant primary literature.

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