AKK Probiotics: The "invisible coach" in the gut, how to help you lose weight while lying down?
Editor's Note: Partnership by MoonBio Original
The following article is from MoonBio Health, written by Xiaomu.
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The team of Dutch scientist Mireille Derrien discovered a type of bacteria that "likes to eat mucus" in human feces. They gave it an amusing name - Akkermansia muciniphila(Akkermansia muciniphilaknown as AKK probiotics), in honor of the renowned Dutch microbial ecologist Antoon D. L. Akkermans. At that time, it was like a "ninth-grade unknown figure" in the entertainment industry, and no one paid any attention to it.
The Patrice D. Cani team from the University of Leuven in Belgium discovered that in mice with obesity and type 2 diabetes, the abundance of the AKK bacteria decreased. However, after supplementing with AKK bacteria, the metabolic disorders induced by a high-fat diet were effectively reversed, resulting in reduced fat and improved insulin sensitivity! Since then, this "little unknown" has embarked on a path of comeback (reversal of fortune)， and the research papers about it have skyrocketed from a few per year to hundreds.
The Patrice D. Cani team published a significant study in "Nature Medicine": A randomized, double-blind, placebo-controlled trial targeting overweight/obese individuals with insulin resistance demonstrated that supplementing with pasteurized AKK bacteria significantly improved insulin sensitivity, reduced insulinemia and total cholesterol, and decreased body weight, body fat, and hip circumference. Since then, AKK bacteria has become the "top figure" in the field of glycolipid metabolism.
Europe has approved the inactivated AKK bacteria produced by Pasteur as a new food ingredient. Since then, the AKK bacteria have successively obtained official certifications from multiple countries such as the United States, Canada, and New Zealand. They will enter the Chinese consumer market in 2024 and are hailed as "the next-generation probiotic star", and even have been called by the media as "the secret of youth in the intestines"!
AKK probiotic | picture from:Derrien M et al. International journal of systematic and evolutionary microbiology, in 2004.
❖Scientific verification:A French clinical trial showed that after 3 months of taking the AKK bacteria supplement, the average amount of visceral fat in overweight individuals decreased by 15.7%.
❖Detailed Explanation:It is like the "fitness coach" in your intestines, helping you burn fat secretly without the need for exercise. (Note: It cannot completely replace a healthy diet!)
❖Amazing Discovery: In animal experiments, the effect of the AKK bacteria in improving blood sugar levels is comparable to that of the diabetes medication "Metformin".
❖Significance:For people with diabetes or insulin resistance, this is truly like "a natural blood sugar control medicine delivered by the intestines".
❖Working principle:The AKK bacteria specifically repair the "leaks" in the intestinal mucosa, preventing harmful substances from "leaking" into the bloodstream and alleviating inflammatory bowel disease.
❖Detailed Explanation:想象你的肠道是一堵墙，AKK菌就是勤劳的“泥瓦匠”，天天帮你补裂缝。
❖Amazing discovery:For patients with colorectal cancer who receive PD-1 immunotherapy, if there are abundant AKK bacteria in their bodies, the therapeutic effect will increase by nearly 40%.
❖Detailed Explanation:The AKK bacteria act like the "personal trainers" for immune cells, teaching them to "attack the enemy" (such as cancer cells) more precisely.
❖Research has proven that:After supplementing AKK bacteria to the elderly mice, the rate of cognitive decline was reduced by 30%.
❖Efficacy Reputation:Because it specifically targets the "aging and relaxation" of cells, it is known as "the hyaluronic acid in the intestines".
AKK Bacteria Effect Illustration | Source: Beibei & Moon Bio Hand-drawn
Do you think that's all? No!The AKK bacteria have also demonstrated significant potential in the intervention of diseases such as epilepsy, neurodegenerative disorders, and hypertension.,It's truly a "all-rounder"!
Choose supplements containing the AKK bacteria (such as AKM Lab-01®）
● Polyphenol Package:Blueberries, dark chocolate, green tea (the favorites of the AKK bacteria)
● Dietary Fiber:Whole grains, oats, apples (the "nutritious meal" for AKK bacteria)
● Stay away from the "blacklist":High-sugar and high-fat junk food (the AKK bacteria will "lose their fat content")
[3]Depommier C, Everard A, Druart C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study[J]. Nature medicine, 2019, 25(7): 1096-1103.
[4]Jian H, Liu Y, Wang X, et al. Akkermansia muciniphila as a next-generation probiotic in modulating human metabolic homeostasis and disease progression: a role mediated by gut–liver–brain axes? [J]. International Journal of Molecular Sciences, 2023, 24(4): 3900.
