Coenzyme Q10 activates myocardial mitochondrial oxidative phosphorylation and maintains cardiac pumping function Literature

The following is the basis of the literature on the activation of myocardial mitochondrial oxidative phosphorylation by coenzyme Q10 and the maintenance of cardiac pumping function:

1. Activation of myocardial mitochondrial oxidative phosphorylation

Research:Littarru, G. P., & Langsjoen, P. (2007). Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion, 7, S168-S174.

Conclusion:Coenzyme Q10 is a key component of the mitochondrial electron transport chain, participating in the oxidative phosphorylation process and promoting ATP production, especially in cardiomyocytes.

Research: Ernster, L., & Dallner, G. (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, 1271(1), 195-204.

Conclusion:Coenzyme Q10 is essential for energy metabolism in cardiomyocytes by participating in electron transfer and proton transfer and directly supporting mitochondrial oxidative phosphorylation.

2. Maintenance of heart pumping function

Research:Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., … & Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC: Heart Failure, 2(6), 641-649.

Conclusion:Studies have shown that coenzyme Q10 significantly improves heart pumping function and reduces the risk of cardiovascular events in patients with chronic heart failure.

研究：Langsjoen, P. H., & Langsjoen, A. M. (2008). Supplemental ubiquinol in patients with advanced congestive heart failure. BioFactors, 32(1-4), 119-128.

CONCLUSION: Coenzyme Q10 has a positive effect on maintaining the pumping function of the heart by improving the energy metabolism of cardiomyocytes and enhancing the contractile function of the heart.