{"id":146,"date":"2025-03-01T12:11:35","date_gmt":"2025-03-01T04:11:35","guid":{"rendered":"https:\/\/akkbio.com\/?p=146"},"modified":"2025-06-04T13:58:17","modified_gmt":"2025-06-04T05:58:17","slug":"focus-and-cognitive-function","status":"publish","type":"post","link":"https:\/\/akkbio.com\/en\/focus-and-cognitive-function\/","title":{"rendered":"Coenzyme Q10 activates myocardial mitochondrial oxidative phosphorylation and maintains cardiac pumping function Literature"},"content":{"rendered":"
\n

The following is the basis of the literature on the activation of myocardial mitochondrial oxidative phosphorylation by coenzyme Q10 and the maintenance of cardiac pumping function:<\/h4>\n

1. Activation of myocardial mitochondrial oxidative phosphorylation<\/h5>\n

Research:<\/strong>Littarru, G. P., & Langsjoen, P. (2007). Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion, 7, S168-S174.<\/p>\n

Conclusion:<\/strong>Coenzyme Q10 is a key component of the mitochondrial electron transport chain, participating in the oxidative phosphorylation process and promoting ATP production, especially in cardiomyocytes.<\/p>\n

Research: Ernster, L., & Dallner, G. (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et Biophysica Acta (BBA) \u2013 Molecular Basis of Disease, 1271(1), 195-204.<\/p>\n

Conclusion:<\/strong>Coenzyme Q10 is essential for energy metabolism in cardiomyocytes by participating in electron transfer and proton transfer and directly supporting mitochondrial oxidative phosphorylation.<\/p>\n

 <\/p>\n

2. Maintenance of heart pumping function<\/h5>\n

Research:<\/strong>Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., … & Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC: Heart Failure, 2(6), 641-649.<\/p>\n

Conclusion:<\/strong>Studies have shown that coenzyme Q10 significantly improves heart pumping function and reduces the risk of cardiovascular events in patients with chronic heart failure.<\/p>\n

Research: Langsjoen, P. H., & Langsjoen, A. M. (2008). Supplemental ubiquinol in patients with advanced congestive heart failure. BioFactors, 32(1-4), 119-128.<\/p>\n

 <\/p>\n

CONCLUSION: Coenzyme Q10 has a positive effect on maintaining the pumping function of the heart by improving the energy metabolism of cardiomyocytes and enhancing the contractile function of the heart.<\/h4>\n<\/div>\n

\"\"<\/p>","protected":false},"excerpt":{"rendered":"

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