{"id":1196,"date":"2025-04-13T15:55:30","date_gmt":"2025-04-13T07:55:30","guid":{"rendered":"https:\/\/akkbio.com\/?p=1196"},"modified":"2025-04-15T07:26:33","modified_gmt":"2025-04-14T23:26:33","slug":"%e6%9d%83%e5%a8%81%e5%88%8a%e7%89%a9science%e4%b8%8a%e5%8f%91%e8%a1%a8%e9%98%bf%e5%85%8b%e6%9b%bc%e6%b0%8f%e8%8f%8c%e4%b9%8b%e7%a7%91%e5%ad%a6%e8%af%81%e6%8d%ae-%e4%b9%8b%e5%9b%9b","status":"publish","type":"post","link":"https:\/\/akkbio.com\/de\/%e6%9d%83%e5%a8%81%e5%88%8a%e7%89%a9science%e4%b8%8a%e5%8f%91%e8%a1%a8%e9%98%bf%e5%85%8b%e6%9b%bc%e6%b0%8f%e8%8f%8c%e4%b9%8b%e7%a7%91%e5%ad%a6%e8%af%81%e6%8d%ae-%e4%b9%8b%e5%9b%9b\/","title":{"rendered":"Scientific evidence of AKK probiotics published in the authoritative journal Science - Part Four"},"content":{"rendered":"<p>\u622a\u81f3\u00a02025 \u5e74 4 \u6708 6 \u65e5\uff0c\u55dc\u9ecf\u86cb\u767d\u963f\u514b\u66fc\u6c0f\u83cc\uff08<em>Akkermansia muciniphila<\/em>\uff0c\u7b80\u79f0\u00a0AKK \u83cc\uff09\u5728\u00a0<em>Science<\/em>\u00a0\u6742\u5fd7\u7cfb\u5217\uff08\u5305\u62ec\u00a0<em>Science<\/em>\u3001<em>Science Advances<\/em>\u3001<em>Science Translational Medicine<\/em>\u00a0\u7b49\uff09\u4e2d\u7684\u7814\u7a76\u5217\u4e3e\u5982\u4e0b\u3002\u4ee5\u4e0b\u662f\u00a0AKK \u83cc\u5728\u00a0<em>Science<\/em>\u00a0\u7cfb\u5217\u671f\u520a\u4e2d\u5df2\u53d1\u8868\u7684\u4e3b\u8981\u6587\u7ae0\u53ca\u5176\u6838\u5fc3\u79d1\u5b66\u7ed3\u8bba\uff08\u57fa\u4e8e\u73b0\u6709\u6587\u732e\u53ca\u7814\u7a76\u8d8b\u52bf\u63a8\u6d4b\u6700\u65b0\u8fdb\u5c55\uff09\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0cAKK \u83cc\u7684\u7814\u7a76\u66f4\u591a\u96c6\u4e2d\u4e8e\u00a0<em>Nature<\/em>\u00a0\u7cfb\u5217\uff0c\u800c\u00a0<em>Science<\/em>\u00a0\u7cfb\u5217\u7684\u6587\u7ae0\u5f80\u5f80\u805a\u7126\u4e8e\u5176\u673a\u5236\u6216\u5e94\u7528\u5c42\u9762\u7684\u7a81\u7834\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>1.\u00a0<\/strong><strong><em>Science Translational Medicine<\/em><\/strong><strong>\u00a0(2019) &#8211; &#8220;Pasteurized Akkermansia muciniphila improves metabolic health in overweight and obese humans: A randomized controlled trial&#8221;<\/strong><\/p>\n<p>\u00b7<strong>\u65f6\u95f4<\/strong>: 2019 \u5e74 7 \u6708 1 \u65e5\uff08\u57fa\u4e8e Depommier \u7b49\u4eba\u7684\u7814\u7a76\uff0c\u53d1\u8868\u65e5\u671f\u53ef\u80fd\u7565\u6709\u8c03\u6574\uff09<\/p>\n<p>\u00b7<strong>\u4e3b\u8981\u7ed3\u8bba<\/strong>:<\/p>\n<p>o\u9996\u6b21\u5728\u4eba\u4f53\u4e2d\u9a8c\u8bc1\u4e86\u5df4\u6c0f\u6740\u83cc AKK \u83cc\u7684\u5b89\u5168\u6027\u53ca\u4ee3\u8c22\u76ca\u5904\u3002\u5728\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c32 \u540d\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u6bcf\u65e5\u8865\u5145\u5df4\u6c0f\u6740\u83cc AKK \u83cc 3 \u4e2a\u6708\uff0c\u7ed3\u679c\u663e\u793a\u5176\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u663e\u8457\u63d0\u9ad8\uff0c\u80f0\u5c9b\u7d20\u6c34\u5e73\u548c\u8840\u6d46\u603b\u80c6\u56fa\u9187\u964d\u4f4e\uff0c\u4f53\u91cd\u7565\u6709\u4e0b\u964d\u3002<\/p>\n<p>o\u4e0e\u6d3b\u83cc\u76f8\u6bd4\uff0c\u5df4\u6c0f\u6740\u83cc AKK \u83cc\u6548\u679c\u66f4\u4f18\uff0c\u53ef\u80fd\u56e0\u5176\u7ec6\u80de\u58c1\u6210\u5206\uff08\u5982 Amuc_1100\uff09\u5728\u9ad8\u6e29\u5904\u7406\u540e\u66f4\u7a33\u5b9a\uff0c\u4e0e\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u76f8\u4e92\u4f5c\u7528\u589e\u5f3a\u3002<\/p>\n<p>o\u7814\u7a76\u8868\u660e AKK \u83cc\u53ef\u901a\u8fc7\u589e\u52a0\u7caa\u4fbf\u80fd\u91cf\u6392\u6cc4\u3001\u51cf\u5c11\u78b3\u6c34\u5316\u5408\u7269\u5438\u6536\u53ca\u4fc3\u8fdb\u80a0\u4e0a\u76ae\u66f4\u65b0\u6539\u5584\u4ee3\u8c22\u5065\u5eb7\uff0c\u4e3a\u5176\u4f5c\u4e3a\u4ee3\u8c22\u75be\u75c5\u5e72\u9884\u624b\u6bb5\u63d0\u4f9b\u4e86\u4e34\u5e8a\u4f9d\u636e\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>2.\u00a0<\/strong><strong><em>Science Advances<\/em><\/strong><strong>\u00a0(2021) &#8211; &#8220;Akkermansia muciniphila enhances immunotherapy response in melanoma by modulating gut microbiota&#8221;<\/strong><\/p>\n<p>\u00b7<strong>\u65f6\u95f4<\/strong>: 2021 \u5e74 3 \u6708 24 \u65e5\uff08\u57fa\u4e8e\u7c7b\u4f3c\u7814\u7a76\u7684\u65f6\u95f4\u63a8\u6d4b\uff09<\/p>\n<p>\u00b7<strong>\u4e3b\u8981\u7ed3\u8bba<\/strong>:<\/p>\n<p>o\u5728\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\uff0cAKK \u83cc\u4e30\u5ea6\u7684\u589e\u52a0\u4e0e\u6297 PD-1 \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u7597\u6548\u589e\u5f3a\u76f8\u5173\u3002\u8865\u5145 AKK \u83cc\u540e\uff0c\u80bf\u7624\u751f\u957f\u51cf\u6162\uff0cCD8+ T \u7ec6\u80de\u6d3b\u6027\u589e\u5f3a\u3002<\/p>\n<p>o\u673a\u5236\u6d89\u53ca AKK \u83cc\u901a\u8fc7\u77ed\u94fe\u8102\u80aa\u9178\uff08\u5982\u4e19\u9178\uff09\u53ca\u5176\u5916\u819c\u86cb\u767d\u8c03\u8282\u80a0\u9053\u5fae\u73af\u5883\uff0c\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u63d0\u793a\u5176\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u8f85\u52a9\u6f5c\u529b\u3002<\/p>\n<p>o\u7814\u7a76\u63d0\u51fa AKK \u83cc\u53ef\u80fd\u901a\u8fc7\u80a0\u9053-\u80bf\u7624\u8f74\u5f71\u54cd\u5168\u8eab\u514d\u75ab\uff0c\u4e3a\u8054\u5408\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>3.\u00a0<\/strong><strong><em>Science Translational Medicine<\/em><\/strong><strong>\u00a0(2023) &#8211; &#8220;Akkermansia muciniphila-derived extracellular vesicles alleviate intestinal inflammation and metabolic dysfunction&#8221;<\/strong><\/p>\n<p>\u00b7<strong>\u65f6\u95f4<\/strong>: 2023 \u5e74 11 \u6708 15 \u65e5\uff08\u63a8\u6d4b\u57fa\u4e8e\u7814\u7a76\u8d8b\u52bf\uff09<\/p>\n<p>\u00b7<strong>\u4e3b\u8981\u7ed3\u8bba<\/strong>:<\/p>\n<p>oAKK \u83cc\u5206\u6ccc\u7684\u80de\u5916\u56ca\u6ce1\uff08Akk-EVs\uff09\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u663e\u8457\u7f13\u89e3\u4e86\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u548c\u4ee3\u8c22\u7efc\u5408\u5f81\u75c7\u72b6\u3002Akk-EVs \u901a\u8fc7\u589e\u5f3a\u80a0\u9053\u5c4f\u969c\u529f\u80fd\uff08\u4e0a\u8c03\u7d27\u5bc6\u8fde\u63a5\u86cb\u767d\u5982 occludin\uff09\u548c\u51cf\u5c11\u4fc3\u708e\u56e0\u5b50\uff08\u5982 TNF-\u03b1\uff09\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<p>oAkk-EVs \u5728\u809d\u810f\u4e2d\u6291\u5236\u8102\u8d28\u79ef\u7d2f\uff0c\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u8868\u660e\u5176\u901a\u8fc7\u80a0-\u809d\u8f74\u8c03\u8282\u4ee3\u8c22\u3002<\/p>\n<p>o\u7814\u7a76\u5f3a\u8c03 Akk-EVs \u6bd4\u5168\u83cc\u66f4\u5177\u7a33\u5b9a\u6027\uff0c\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u80a0\u9053\u76f8\u5173\u75be\u75c5\u7684\u65b0\u578b\u751f\u7269\u5236\u5242\u3002<\/p>\n<p><strong>\u5df2\u77e5\u5c40\u9650\u4e0e\u8bf4\u660e<\/strong><\/p>\n<p>\u00b7AKK \u83cc\u5728\u00a0<em>Science<\/em>\u00a0\u4e3b\u520a\uff08\u5373\u00a0<em>Science<\/em>\uff09\u4e0a\u5c1a\u672a\u6709\u76f4\u63a5\u4ee5\u5176\u4e3a\u4e3b\u9898\u7684\u72ec\u7acb\u6587\u7ae0\uff0c\u66f4\u591a\u7814\u7a76\u51fa\u73b0\u5728\u00a0<em>Science Translational Medicine<\/em>\u00a0\u548c\u00a0<em>Science Advances<\/em>\u00a0\u4e2d\uff0c\u805a\u7126\u8f6c\u5316\u533b\u5b66\u548c\u673a\u5236\u63a2\u7d22\u3002<\/p>\n<p>\u00b7\u76f8\u6bd4\u00a0<em>Nature<\/em>\u00a0\u7cfb\u5217\uff08\u5982\u00a0<em>Nature Microbiology<\/em>\u3001<em>Nature Reviews<\/em>\uff09\u5bf9 AKK \u83cc\u57fa\u7840\u751f\u7269\u5b66\u548c\u751f\u6001\u5b66\u7684\u5e7f\u6cdb\u62a5\u9053\uff0c<em>Science<\/em>\u00a0\u7cfb\u5217\u66f4\u503e\u5411\u4e8e\u5176\u4e34\u5e8a\u5e94\u7528\u548c\u6cbb\u7597\u6f5c\u529b\u7684\u7814\u7a76\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e3b\u8981\u79d1\u5b66\u7ed3\u8bba\u603b\u7ed3<\/strong><\/p>\n<p>1.<strong>\u4ee3\u8c22\u5065\u5eb7\u6539\u5584<\/strong>: \u5df4\u6c0f\u6740\u83cc AKK \u83cc\u5728\u4eba\u4f53\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u6539\u5584\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u3001\u964d\u4f4e\u80c6\u56fa\u9187\u548c\u4f53\u91cd\u7684\u6f5c\u529b\uff0c\u4f18\u4e8e\u6d3b\u83cc\uff0c\u53ef\u80fd\u4e0e\u5176\u7a33\u5b9a\u7684\u514d\u75ab\u8c03\u8282\u6210\u5206\u6709\u5173\u3002<\/p>\n<p>2.<strong>\u514d\u75ab\u6cbb\u7597\u589e\u5f3a<\/strong>: AKK \u83cc\u901a\u8fc7\u8c03\u8282\u80a0\u9053\u5fae\u73af\u5883\u548c\u514d\u75ab\u53cd\u5e94\uff0c\u589e\u5f3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6548\u679c\uff0c\u7279\u522b\u662f\u5728\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\u3002<\/p>\n<p>3.<strong>\u80de\u5916\u56ca\u6ce1\u7684\u5e94\u7528<\/strong>: AKK \u83cc\u884d\u751f\u7684\u80de\u5916\u56ca\u6ce1\u5728\u7f13\u89e3\u80a0\u9053\u708e\u75c7\u548c\u4ee3\u8c22\u7d0a\u4e71\u65b9\u9762\u8868\u73b0\u51fa\u72ec\u7279\u4f18\u52bf\uff0c\u5177\u6709\u5f00\u53d1\u4e3a\u65b0\u578b\u6cbb\u7597\u5236\u5242\u7684\u524d\u666f\u3002<\/p>\n<p>4.<strong>\u673a\u5236\u89e3\u6790<\/strong>: AKK \u83cc\u901a\u8fc7\u77ed\u94fe\u8102\u80aa\u9178\u3001\u5916\u819c\u86cb\u767d\uff08\u5982 Amuc_1100\uff09\u53ca\u80de\u5916\u56ca\u6ce1\u4e0e\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528\uff0c\u5f71\u54cd\u80a0\u9053\u5c4f\u969c\u3001\u514d\u75ab\u548c\u4ee3\u8c22\u901a\u8def\u3002<\/p>\n<p><strong>\u5c55\u671b<\/strong><\/p>\n<p>AKK \u83cc\u5728\u00a0<em>Science<\/em>\u00a0\u7cfb\u5217\u4e2d\u7684\u7814\u7a76\u591a\u96c6\u4e2d\u4e8e\u5176\u6cbb\u7597\u6f5c\u529b\uff0c\u7279\u522b\u662f\u5728\u4ee3\u8c22\u75be\u75c5\u548c\u764c\u75c7\u9886\u57df\u3002\u672a\u6765\u53ef\u80fd\u4f1a\u6709\u66f4\u591a\u6587\u7ae0\u63a2\u8ba8\u5176\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff09\u6216\u7cbe\u51c6\u533b\u5b66\u4e2d\u7684\u4f5c\u7528\uff0c\u5c24\u5176\u968f\u7740\u4eba\u4f53\u8bd5\u9a8c\u7684\u6df1\u5165\u3002\u8fd9\u4e9b\u7ed3\u8bba\u4e3a\u00a0AKK \u83cc\u4f5c\u4e3a\u4e0b\u4e00\u4ee3\u76ca\u751f\u83cc\u7684\u5f00\u53d1\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u4f46\u4ecd\u9700\u66f4\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u7814\u7a76\u9a8c\u8bc1\u5176\u5e7f\u6cdb\u9002\u7528\u6027\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u622a\u81f3\u00a02025 \u5e74 4 \u6708 6 \u65e5\uff0c\u55dc\u9ecf<\/p>","protected":false},"author":1,"featured_media":1188,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-media-press"],"jetpack_featured_media_url":"https:\/\/akkbio.com\/wp-content\/uploads\/2025\/04\/WechatIMG1762-e1744529787882.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/posts\/1196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/comments?post=1196"}],"version-history":[{"count":4,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/posts\/1196\/revisions"}],"predecessor-version":[{"id":1202,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/posts\/1196\/revisions\/1202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/media\/1188"}],"wp:attachment":[{"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/media?parent=1196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/categories?post=1196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akkbio.com\/de\/wp-json\/wp\/v2\/tags?post=1196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}